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Proteins/UNIPROT:Q15118
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia..
Function from UniProtKB (Q15118), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
76 statements
76 statements · 4 reference databases · Subject: PDK1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
MAM00219c+ATPMAM00220c+ADP+proton
Catalysed by PDK4 or PDK2 or PDK3 or PDK1
Reaction pageLeft to rightBalance undeterminableEC 2.7.11.2cytosol
Human-GEM MAR09517CC BY 4.0Reference data
L-seryl-[pyruvate dehydrogenase E1 alpha subunit]+ATP(4-)O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]+ADP(3-)+
4 names
Resolves to: PDK1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23052CC BY 4.0Reference data