Pathway
Regulation of FOXO transcriptional activity by acetylation
Oxidative stress induces acetylation of FOXO transcription factors, which changes the preference of FOXO transcription factors for target DNA sequences. Histone deacetylases SIRT1 and SIRT3 deacetylate FOXO transcription factors (Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, reviewed by Hisahara et al. 2005).
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Acetylation can also regulate FOXO localization, overriding phosphorylation.
REACT:R-HSA-9617629Reactome
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: Regulation of FOXO transcriptional activity by acetylation · Sources: Reactome
- CREBBP participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- EP300 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- FOXO1 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- FOXO3 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- FOXO4 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- KAT2B participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- SIRT1 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- SIRT3 participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- TXN participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only
- TXNIP participates in Regulation of FOXO transcriptional activity by acetylationProteinReactome R-HSA-9617629Inferred only