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Proteins/UNIPROT:P04908
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Function from UniProtKB (P04908), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
184 statements
184 statements · 4 reference databases · Subject: H2AC4; H2AC8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
7 names
Resolves to: H2AC4; H2AC8