Proteins/UNIPROT:Q9UIH9

KLF15

ProteinUNIPROT:Q9UIH9

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation..

Function from UniProtKB (Q9UIH9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 4 reference databases · Subject: KLF15 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

KLF15 covaries with C1orf198ProteinHetionet hetionet:covaries:28999-84886Inferred only
KLF15 covaries with IL15RAProteinHetionet hetionet:covaries:28999-3601Inferred only
KLF15 covaries with PDCD2ProteinHetionet hetionet:covaries:28999-5134Inferred only
KAT2B interacts with KLF15ProteinHetionet hetionet:interacts:28999-8850Inferred only
SNX13 interacts with KLF15ProteinHetionet hetionet:interacts:23161-28999Inferred only
TCF21 interacts with KLF15ProteinHetionet hetionet:interacts:28999-6943Inferred only
KLF15 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
KLF15 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionPathwayReactome R-HSA-1368108Inferred only
KLF15 participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
KLF15 participates in Transcriptional cascade regulating adipogenesisPathwayWikiPathways WP4211Inferred only
KLF15 participates in White fat cell differentiationPathwayWikiPathways WP4149Inferred only
KLF15 regulates negative regulation of collagen biosynthetic processBiological processgene ontology Q9UIH9|GO:0032966Inferred only

Show the remaining 4

KLF15 regulates negative regulation of peptidyl-lysine acetylationBiological processgene ontology Q9UIH9|GO:2000757Inferred only
KLF15 regulates negative regulation of transforming growth factor beta productionBiological processgene ontology Q9UIH9|GO:0071635Inferred only
KLF15 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UIH9|GO:0045944Inferred only
KLF15 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UIH9|GO:0006357Inferred only

Other names

3 names

Resolves to: KLF15

Also called: Kidney-enriched krueppel-like factorKKLFKrueppel-like factor 15

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