Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins.
REACT:R-HSA-2032785Reactome
What the reference databases state
Statements
14 statements
14 statements · 1 reference database · Subject: YAP1- and WWTR1 (TAZ)-stimulated gene expression · Sources: Reactome
- CCN2 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- GATA4 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- HIPK1 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- HIPK2 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- KAT2B participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- NKX2-5 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- NPPA participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- TBX5 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- TEAD1 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- TEAD2 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- TEAD3 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- TEAD4 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
Show the remaining 2
- WWTR1 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only
- YAP1 participates in YAP1- and WWTR1 (TAZ)-stimulated gene expressionProteinReactome R-HSA-2032785Inferred only