Pathway
Signaling by NOTCH1
NOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.
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NOTCH1 receptor presented on the plasma membrane is activated by a membrane bound ligand expressed in trans on the surface of a neighboring cell. In trans, ligand binding triggers proteolytic cleavage of NOTCH1 and results in release of the NOTCH1 intracellular domain, NICD1, into the cytosol.
NICD1 translocates to the nucleus where it associates with RBPJ (also known as CSL or CBF) and mastermind-like (MAML) proteins (MAML1, MAML2 or MAML3; possibly also MAMLD1) to form NOTCH1 coactivator complex. NOTCH1 coactivator complex activates transcription of genes that possess RBPJ binding sites in their promoters.
REACT:R-HSA-1980143Reactome
What the reference databases state
Statements
72 statements
72 statements · 1 reference database · Subject: Signaling by NOTCH1 · Sources: Reactome
- ADAM10 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- ADAM17 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- APH1A participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- APH1B participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- ARRB1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- ARRB2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- CCNC participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- CDK8 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- CNTN1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- CREBBP participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- CUL1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DLK1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
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- DLL1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DLL4 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DNER participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DTX1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DTX2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- DTX4 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- EP300 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC10 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC11 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC3 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC4 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC5 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC6 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC7 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC8 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HDAC9 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HES1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HES5 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HEY1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HEY2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HEYL participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- HIF1A participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- ITCH participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- JAG1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- JAG2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- KAT2A participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- KAT2B participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MAML1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MAML2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MAML3 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MAMLD1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MIB1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MIB2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- MYC participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NBEA participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NCOR1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NCOR2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NCSTN participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NEURL1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NEURL1B participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NOTCH1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- NUMB participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- PSEN1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- PSEN2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- PSENEN participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- RBPJ participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- RBX1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- RPS27A participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- SKP1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- SNW1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- TBL1X participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- TBL1XR1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- TLE1 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- TLE2 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- TLE4 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- UBA52 participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- UBB participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only
- UBC participates in Signaling by NOTCH1ProteinReactome R-HSA-1980143Inferred only