Pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants
As NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signaling. However, once the NICD1 fragment of NOTCH1 is released, PEST domain mutations prolong its half-life and transcriptional activity through interference with FBXW7 (FBW7)-mediated ubiquitination and degradation of NICD1. All NOTCH1 PEST domain mutants annotated here (NOTCH1 Q2395*, NOTCH1 Q2440*, NOTCH1 P2474Afs*4 and NOTCH1 P2514Rfs*4) either have a truncated PEST domain or lack the PEST domain completely.
REACT:R-HSA-2644606Reactome
What the reference databases state
Statements
57 statements
57 statements · 1 reference database · Subject: Constitutive Signaling by NOTCH1 PEST Domain Mutants · Sources: Reactome
- ADAM10 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- ADAM17 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- APH1A participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- APH1B participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- CCNC participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- CDK8 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- CREBBP participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- CUL1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- DLL1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- DLL4 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- EP300 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
Show the remaining 45
- HDAC10 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC11 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC3 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC4 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC5 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC6 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC7 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC8 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HDAC9 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HES1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HES5 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HEY1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HEY2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- HEYL participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- JAG1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- JAG2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- KAT2A participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- KAT2B participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MAML1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MAML2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MAML3 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MAMLD1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MIB1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MIB2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- MYC participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NCOR1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NCOR2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NCSTN participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NEURL1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NEURL1B participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- NOTCH1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- PSEN1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- PSEN2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- PSENEN participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- RBPJ participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- RBX1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- RPS27A participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- SKP1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- SNW1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- TBL1X participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- TBL1XR1 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- UBA52 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- UBB participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only
- UBC participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsProteinReactome R-HSA-2644606Inferred only