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Proteins/UNIPROT:Q9UBC0

ONECUT1

Protein·UNIPROT:Q9UBC0

Open in the graph

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Function from UniProtKB (Q9UBC0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neonatal diabetes mellitus has a germline basis in ONECUT1DiseaseGenCC HGNC:8138|MONDO:0016391Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: ONECUT1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FAM167A covaries with ONECUT1ProteinHetionet hetionet:covaries:3175-83648Inferred only
IGDCC4 covaries with ONECUT1ProteinHetionet hetionet:covaries:3175-57722Inferred only
NTN3 covaries with ONECUT1ProteinHetionet hetionet:covaries:3175-4917Inferred only
OR52J3 covaries with ONECUT1ProteinHetionet hetionet:covaries:119679-3175Inferred only
CREBBP interacts with ONECUT1ProteinHetionet hetionet:interacts:1387-3175Inferred only
FOXA1 interacts with ONECUT1ProteinHetionet hetionet:interacts:3169-3175Inferred only
FOXA2 interacts with ONECUT1ProteinHetionet hetionet:interacts:3170-3175Inferred only
ONECUT1 interacts with KAT2BProteinHetionet hetionet:interacts:3175-8850Inferred only
ONECUT1 interacts with NR0B2ProteinHetionet hetionet:interacts:3175-8431Inferred only
NR3C1 interacts with ONECUT1ProteinHetionet hetionet:interacts:2908-3175Inferred only
ONECUT1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ONECUT1 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only

Show the remaining 12

ONECUT1 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
ONECUT1 participates in Developmental Lineage of Multipotent Pancreatic Progenitor CellsPathwayReactome R-HSA-9937080Inferred only
ONECUT1 participates in Developmental Lineage of Pancreatic Acinar CellsPathwayReactome R-HSA-9925561Inferred only
ONECUT1 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
ONECUT1 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
ONECUT1 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
ONECUT1 participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
ONECUT1 participates in Regulation of gene expression in early pancreatic precursor cellsPathwayReactome R-HSA-210747Inferred only
ONECUT1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsPathwayReactome R-HSA-210744Inferred only
ONECUT1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UBC0|GO:0045944Inferred only
ONECUT1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9UBC0|GO:0006355Inferred only
ONECUT1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UBC0|GO:0006357Inferred only

Other names

5 names

Resolves to: ONECUT1

Also called: HNF-6HNF6HNF6AOne cut domain family member 1One cut homeobox 1

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