NOTCH4 Intracellular Domain Regulates Transcription

In the nucleus, NOTCH4 intracellular domain fragment (NICD4) binds transcription factors RBPJ (CSL) and mastermind family members (MAML1, MAML2 or MAML3) to form the NOTCH4 co-activator complex. The NOTCH4 coactivator complex stimulates transcription of well-established NOTCH targets HES1, HES5, HEY1 and HEY2 in a cellular context-dependent manner (Lin et al. 2002, Raafat et al.2004, Tsunematsu et al. 2004, Bargo et al. 2010). NOTCH4 also stimulates transcription of the FLT4 (VEGFR3) gene, encoding vascular endothelial growth factor receptor-3 and ACTA2 gene, encoding smooth muscle alpha actin.

Summary from Reactome (R-HSA-9013695), read 2026-09-23.