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Proteins/UNIPROT:Q9H0E2
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P)..
Function from UniProtKB (Q9H0E2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
280 statements
280 statements · 4 reference databases · Subject: TOLLIP · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: TOLLIP