Pathway
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
The properties of transcriptional networks in late stage (branching morphogenesis) pancreatic bud precursor cells are inferred from the properties of well-studied networks in mouse models. In mice, committed but undifferentiated epithelial cells are organized into branching ductal structures. At a molecular level, expression of Pdx1, Nkx2.2, and Nkx6.1 is reduced while Hnf6 expression remains high. Hnf6 mediates the continued expression of Onecut3 and Hnf1 beta and epithelial cell proliferation. As expression of Ngn3 (corresponds to human NEUROG3) rises, endocrine differentiation of the epithelial cells begins.
What the reference databases state
Statements
15 statements
15 statements · 1 reference database · Subject: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells · Sources: Reactome
- CREBBP participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- EP300 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- HES1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- HNF1B participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- KAT2A participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- KAT2B participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- MAML1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- MAML2 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- MAML3 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- MAMLD1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- NEUROG3 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- NOTCH1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
Show the remaining 3
- ONECUT1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- RBPJ participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only
- SNW1 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsProteinReactome R-HSA-210744Inferred only