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Proteins/UNIPROT:P02144
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity..
Function from UniProtKB (P02144), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
69 statements
69 statements · 6 reference databases · Subject: MB · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways
2 reactions
Catalysed by MB or EPX or CYGB
Reaction pageLeft to rightBalanced
Rhea RHEA:30275CC BY 4.0Reference data
Fe(III)-heme b-[protein]+nitric oxide+waterFe(II)-heme b-[protein]+nitrite+2hydron
Catalysed by
2 names
Resolves to: MB
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:77711CC BY 4.0Reference data