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Proteins/UNIPROT:Q01968
Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Also, is able to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling..
Function from UniProtKB (Q01968), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
54 statements
54 statements · 5 reference databases · Subject: OCRL · Sources: Hetionet, Reactome, Rhea, UniProt, WikiPathways
6 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+phosphate(3-)
Catalysed by SYNJ2 or OCRL or INPP5E or SYNJ1 or INPP5B
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36cytosol
Human-GEM MAR06552CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+
5 names
Resolves to: OCRL
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36nucleus
Human-GEM MAR08817CC BY 4.0Reference data
CHEBI:57895+waterCHEBI:58414+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or OCRL or INPP5A or INPP5J or INPP5D or INPP5K
Reaction pageLeft to rightBalanced
Rhea RHEA:11392CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data
CHEBI:57836+waterCHEBI:57658+hydrogenphosphate
Catalysed by SYNJ2 or INPPL1 or SYNJ1 or OCRL or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25528CC BY 4.0Reference data