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Proteins/UNIPROT:Q6ZMT4
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate..
Function from UniProtKB (Q6ZMT4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
36 statements
36 statements · 5 reference databases · Subject: KDM7A · Sources: Bgee, gene ontology, Hetionet, Reactome, UniProt
4 reactions
N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3]+2-oxoglutarate(2-)+dioxygenN(6)-methyl-L-lysyl(36)-[histone H3]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM7A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21788CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)+2dioxygenL-lysyl(9)-[histone H3]+
6 names
Resolves to: KDM7A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60188CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3]+22-oxoglutarate(2-)+2dioxygenL-lysyl(27)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM7A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67800CC BY 4.0Reference data
N(6)-methyl-L-lysyl(20)-[histone H4]+2-oxoglutarate(2-)+dioxygenL-lysyl(20)-[histone H4]+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by KDM1A or RAD23A or RAD23B or KDM7A or PHF8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67804CC BY 4.0Reference data