1-O-hexadecyl-sn-glycero-3-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

382 compounds within 3 steps: 11 in 1, 20 in 2, 351 in 3

Three steps

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 more
(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 more
2,4-dinitrophenyl-S-glutathioneReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. transport of arachidonate (cytosol to extracellular)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 moreextracellular space, cytosolOne of 4 routes
N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
Catalysed by LPCAT4, PLB1, PM20D1
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 more
N-(9Z-octadecenoyl)-L-leucineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
Catalysed by LPCAT4, PLB1, PM20D1
N-acetylcadaverineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. N-acetylcadaverine + H2O = cadaverine + acetate
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 6 more
7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 27 morecytosolOne of 2 routes
13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 27 morecytosolOne of 2 routes
13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 more
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 more
acetoacetateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. transport of acetate and acetoacetate (cytosol to extracellular)
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 10 moreextracellular space, cytosolOne of 2 routes
16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 27 morecytosol
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. choline + A = betaine aldehyde + AH2
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more
a phenyl acetateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. a phenyl acetate + H2O = a phenol + acetate + H(+)
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 8 more
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-octadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by LPCAT2, LPCAT1, PAFAH2, PLA2G15
2-nonadioyl-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-nonadioyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by LPCAT2, LPCAT1, PAFAH2, PLA2G15
8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 1 morecytosolOne of 2 routes
1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLA2G4C, TMEM86A, TMEM86B
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 3 more
(7Z)-octadecenoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosolOne of 3 routes
CHEBI:15345Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. Acetoacetate:CoA ligase (AMP-forming)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosolOne of 2 routes
acetylpyruvateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. acetylpyruvate + H2O = acetate + pyruvate + H(+)
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 6 more
pyruvateReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. transport of acetate and pyruvate (cytosol to extracellular)
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 10 moreextracellular space, cytosolOne of 2 routes
all-trans-retinoic acidReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
3. transport of acetate and retinoate (cytosol to extracellular)
Catalysed by LPCAT2, LPCAT1, PLA2G10, PLA2G6 and 8 moreextracellular space, cytosolOne of 2 routes
CHEBI:15380Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 2 morecytosol, mitochondrial matrixOne of 8 routes
CHEBI:15477Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 2 routes
2-methylcrotonoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. Production of Tiglylcarnitine
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 2 morecytosolOne of 2 routes
isobutyryl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 3 routes
3-methylbut-2-enoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. glycine-N-acyltransferase (3-methylcrotonoylglycine)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosol, mitochondrial matrix
isovaleryl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. glycine N-acyltransferase (isovalerylglycine)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 3 routes
arachidonoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. Arachidonate:CoA ligase (AMP-forming)
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 9 morecytosolOne of 14 routes
CHEBI:15519Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. propanoyl-CoA C-acyltransferase
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, peroxisomeOne of 2 routes
palmitoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. Palmitate:CoA ligase (AMP-forming)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 8 morecytosolOne of 11 routes
oleoyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
3. long-chain-fatty-acid-CoA ligase (oleate)
Catalysed by LPCAT4, PLB1, SLC27A2, ACSL4 and 6 morecytosolOne of 14 routes
phenylacetyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. Phenylacetate:CoA ligase
Catalysed by ENPP2, GDPD3, GDPD1, CHATcytosolOne of 3 routes
propionyl-CoAReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. Propanoate:CoA ligase (AMP-forming)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosolOne of 43 routes
L-leucineReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. transport of chloride and choline (cytosol to extracellular)
3. transport of chloride and leucine (cytosol to extracellular)
Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes
12(S)-HPETEReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. arachidonate:oxygen 12-oxidoreductase
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 morecytosolOne of 4 routes
15(S)-HPETEReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. arachidonate:oxygen 15-oxidoreductase
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 3 morecytosolOne of 4 routes
5(S)-HPETEReach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
2. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. Arachidonate:oxygen 5-oxidoreductase
Catalysed by LPCAT4, PLA2G6, PLA2G4A, PLA2G4F and 2 morecytosol
CHEBI:15650Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. N-acetyl-LTE4 to leukotriene E4 conversion
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 32 morecytosolOne of 2 routes
CHEBI:15727Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosol
CHEBI:15746Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. Acetyl-CoA:choline O-acetyltransferase
3. diamine N-acetyltransferase (N1-acetylspermine)
Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 2 morecytosolOne of 2 routes
CHEBI:15971Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
2. transport of chloride and choline (cytosol to extracellular)
3. transport of chloride and histidine (cytosol to extracellular)
Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol
CHEBI:16108Reach from here →
1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
3. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
Catalysed by PLA2G4C, GPCPD1, GPD2cytosol, mitochondrial matrixOne of 2 routes