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Proteins/UNIPROT:P32019
Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events..
Function from UniProtKB (P32019), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: INPP5B · Sources: Hetionet, Reactome, Rhea, UniProt
4 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+phosphate(3-)
Catalysed by SYNJ2 or OCRL or INPP5E or SYNJ1 or INPP5B
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36cytosol
Human-GEM MAR06552CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+
4 names
Resolves to: INPP5B
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36nucleus
Human-GEM MAR08817CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data