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Proteins/UNIPROT:Q86T03
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules. Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1. May play a role in the regulation of cellular cholesterol metabolism..
Function from UniProtKB (Q86T03), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
40 statements
40 statements · 5 reference databases · Subject: PIP4P1 · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways
2 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.78cytosol
Human-GEM MAR06553CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Catalysed by PIP4P1
5 names
Resolves to: PIP4P1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:25674CC BY 4.0Reference data