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Proteins/UNIPROT:Q8N4L2
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity)..
Function from UniProtKB (Q8N4L2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: PIP4P2 · Sources: gene ontology, Hetionet, Rhea, WikiPathways
2 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.78cytosol
Human-GEM MAR06553CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Catalysed by PIP4P1
4 names
Resolves to: PIP4P2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:25674CC BY 4.0Reference data