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(2E)-hexadecenal

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

19 compounds within 3 steps: 2 in 1, 3 in 2, 14 in 3

Does it reach a compound?

One step

hexadecanalReach from here →
1. hexadecanal:NADP+ delta2-oxidoreductase
No catalyst recordedcytosol
(E)-hexadec-2-enoateReach from here →
1. H2O[r] + hexadecenal[r] + NAD+[r] = 2 H+[r] + NADH[r] + (E)-hexadec-2-enoate[r]
Catalysed by ALDH3A2endoplasmic reticulumOne of 3 routes

Two steps

sphinganine 1-phosphateReach from here →
1. hexadecanal:NADP+ delta2-oxidoreductase
2. Sphinganine-1-phosphate pamlmitaldehyde-lyase
Catalysed by SGPL1cytosol
(2E)-hexadecenoyl-CoAReach from here →
1. H2O[r] + hexadecenal[r] + NAD+[r] = 2 H+[r] + NADH[r] + (E)-hexadec-2-enoate[r]
2. (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
Catalysed by ALDH3A2, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum
hexadecanoate

Three steps

CHEBI:1146900Reach from here →
Catalysed by ALDH3A2, SLC27A2, ACSL4, ACSL3 and 8 moreendoplasmic reticulum, cytosolOne of 4 routes
palmitoyl-CoAReach from here →

Reach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2cytosol

Catalysed by ALDH3A2, SLC27A2, ACSL4, ACSL3 and 6 moreendoplasmic reticulum, mitochondrial matrix

CHEBI:16566Reach from here →

hexadecanal:NADP+ delta2-oxidoreductase
Sphinganine-1-phosphate pamlmitaldehyde-lyase
3-sn-phosphatidate phosphohydrolase

Catalysed by SGPL1, PLPP1, PLPP3, PLPP2cytosolOne of 2 routes

O-phosphoethanolamineReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
Sphinganine-1-phosphate pamlmitaldehyde-lyase
Sphinganine-1-phosphate pamlmitaldehyde-lyase

Catalysed by SGPL1cytosol, endoplasmic reticulum

all-trans-retinyl hexadecanoateReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, RPE65cytosol

S-hexadecanoyl-N-acetylcysteamineReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, PPT1 and 1 morecytosol

S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, PPT1cytosol

16-hydroxyhexadecanoateReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, CYP4A11 and 2 morecytosol

hexadecanoyl-CoAReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, SLC27A2 and 10 morecytosolOne of 2 routes

octanoyl-CoAReach from here →

H2O[r] + hexadecenal[r] + NAD+[r] = 2 H+[r] + NADH[r] + (E)-hexadec-2-enoate[r]
(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
Beta Oxidation Fatty Acid

Catalysed by ALDH3A2, SLC27A2, ACSL4, ACSL3 and 7 moreendoplasmic reticulum, mitochondrial matrix

sphinganineReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
Sphinganine-1-phosphate pamlmitaldehyde-lyase
sphinganine 1-phosphate + H2O = sphinganine + phosphate

Catalysed by SGPL1, SGPP2, SGPP1cytosol

phosphoethanolamineReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
Sphinganine-1-phosphate pamlmitaldehyde-lyase
sphinganine 1-phosphate = hexadecanal + phosphoethanolamine

Catalysed by SGPL1cytosol

N-hexadecanoylsphing-4-enineReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, NAAA and 3 morecytosol

(R)-2-hydroxyhexadecanoateReach from here →

hexadecanal:NADP+ delta2-oxidoreductase
hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
hexadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, FA2Hcytosol