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Reach

guanidinoacetate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

510 compounds within 3 steps: 4 in 1, 102 in 2, 404 in 3

Does it reach a compound?

Two steps

(2S)-2-aminobutanoateReach from here →
1. L-Arginine:glycine amidinotransferase
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by GATM, AGXT2cytosol
glycodeoxycholateReach from here →
1. L-Arginine:glycine amidinotransferase
2. Glycodeoxycholate amidohydrolase
Catalysed by GATMcytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. L-Arginine:glycine amidinotransferase
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by GATM, GLYATL2cytosol
N-eicosanoylglycinateReach from here →
1. L-Arginine:glycine amidinotransferase
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by GATM, BAATcytosol
N-docosanoylglycineReach from here →
1. L-Arginine:glycine amidinotransferase
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by GATM, BAATcytosol
N-hexacosanoylglycineReach from here →
1. L-Arginine:glycine amidinotransferase
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by GATM, BAATcytosol

Three steps

beta-carbolineReach from here →
Catalysed by GATM, SLC7A6cytosol, extracellular space
2-hydroxybutyric acidReach from here →
Catalysed by SLC26A4, SLC16A4 and 1 more

Page 3 of 11

, SLC16A5

, SLC16A7

extracellular space, cytosol

One of 2 routes

3-methyl-2-oxobutanoateReach from here →

L-Arginine:glycine amidinotransferase
transport of arginine and valine (cytosol to extracellular)
L-Valine:2-oxoglutarate aminotransferase

Catalysed by GATM, SLC7A6, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 3 routes

2-phenylpropan-2-olReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

Catalysed by GATM, GSS, CLIC2, GPX1 and 2 morecytosol

a hydroxy polyunsaturated fatty acidReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Catalysed by GATM, GSS, GPX1, GPX2 and 1 morecytosol

AReach from here →

L-Arginine:glycine amidinotransferase
transport of arginine and cysteine (cytosol to extracellular)
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GATM, SLC7A6, MOCOScytosol, extracellular space

(5E)-tetradecenoyl-(R)-carnitineReach from here →

Transport of Guanidinoacetic Acid
Carnitine Transport by Atb0
carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

Catalysed by SLC6A14, CPT1A, CPT1C, CPT1Bextracellular space, cytosolOne of 7 routes

tauroursodeoxycholateReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

Catalysed by GATM, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →

L-Arginine:glycine amidinotransferase
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

Catalysed by GATM, GLYATL2, ALOX15, ALOX12cytosol

N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →

L-Arginine:glycine amidinotransferase
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

Catalysed by GATM, GLYATL2, ALOX15B, ALOX15 and 1 morecytosol

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

Catalysed by GATM, GSS, GPX1, GPX4cytosol

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
glutathione transferase (GSH)

Catalysed by GATM, GSS, PTGES, MGST3 and 19 morecytosolOne of 5 routes

pregnenolone sulfateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and sulfate (cytosol to extracellular)
Steryl-Sulfatase

Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

androsterone 3alpha-sulfateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and sulfate (cytosol to extracellular)
steroid sulfatase (androsterone sulfate)

Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

prostaglandin E3Reach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin E3 (cytosol to extracellular)

Catalysed by GATM, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin A2 (cytosol to extracellular)

Catalysed by GATM, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin B1 (cytosol to extracellular)

Catalysed by GATM, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and leukotriene F4 (cytosol to extracellular)

Catalysed by GATM, GSScytosol, extracellular spaceOne of 4 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

L-Arginine:glycine amidinotransferase
L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by GATM, SLC7A9, SLC25A29, SLC7A6 and 1 morecytosol, inner side of the membrane, outer side of the membrane

prostaglandin A2-S-(R)-glutathioneReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by GATM, GSS, GSTA1, GSTM1cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by GATM, GSS, GSTP1, GSTM1cytosol

prostaglandin J2-S-(R)-glutathioneReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by GATM, GSS, GSTA1, GSTP1 and 1 morecytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by GATM, GSS, GSTP1, GSTM1cytosol

2,4-dinitrophenyl-S-glutathioneReach from here →

L-Arginine:glycine amidinotransferase
bile acid-CoA: amino acid N-acyltransferase
solute carrier organic anion transporter (glycocholate)

Catalysed by GATM, BAAT, SLCO1A2, SLCO1B3cytosol, peroxisome, extracellular spaceOne of 11 routes

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

L-Arginine:glycine amidinotransferase
transport of arginine and phenylalanine (cytosol to extracellular)
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by GATM, SLC7A6, PM20D1cytosol, extracellular space

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

L-Arginine:glycine amidinotransferase
transport of arginine and phenylalanine (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by GATM, SLC7A6, PM20D1cytosol, extracellular space

N-(9Z-octadecenoyl)-L-leucineReach from here →

L-Arginine:glycine amidinotransferase
transport of arginine and leucine (cytosol to extracellular)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by GATM, SLC3A2, SLC7A6, SLC7A7 and 1 morecytosol, extracellular space

cholesterol sulfateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and sulfate (cytosol to extracellular)
Steryl-Sulfatase

Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and sulfate (cytosol to extracellular)
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

acetoacetateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and formate (cytosol to extracellular)
transport of acetoacetate and formate (cytosol to extracellular)

Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

Catalysed by GATM, GSS, GSTM4, LTC4Scytosol

an aryl sulfateReach from here →

Transport of Guanidinoacetic Acid
transport of chloride and sulfate (cytosol to extracellular)
an aryl sulfate + H2O = a phenol + sulfate + H(+)

Catalysed by SLC26A6, ARSL, ARSF, ARSK and 3 moreextracellular space, cytosol

S-methyl glutathioneReach from here →

L-Arginine:glycine amidinotransferase
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by GATM, GSS, MMACHCcytosol

N-octanoyl-(2S)-hydroxyglycineReach from here →

L-Arginine:glycine amidinotransferase
glycine + 2-oxoglutarate = glyoxylate + L-glutamate
N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate