3,5-diiodo-L-tyrosine

Three steps

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by IYD, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• glutathione disulfideReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3, GPX5 and 8 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by IYD, AADAT, AGXT2One of 2 routes

• histamineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by IYD, SLC7A13, PAICSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (3S)-citramalyl-CoAReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• 5-amino-2-oxopentanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• S-sulfanylglutathioneReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3, SQORcytosol, extracellular space, mitochondrial matrix

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by IYD, AADAT, GLYATL2One of 2 routes

• 4-aminobutanoateReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A12extracellular space, cytosolOne of 4 routes

• dopamineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

• glycolithocholate 3-sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by TPO, DIO1, DIO3, ACAD10cytosol

• estrone 3-sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• N-benzoylglycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by IYD, AADATmitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by IYD, SLC7A13, SLC25A12, SLC25A13inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by TPO, SLCO1A2, SLCO1B3, GGTLC3 and 5 morecytosol, extracellular spaceOne of 4 routes

• Fe(II)-heme aReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by TPO, DIO1, DIO3, COX15cytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• Mo-molybdopterinReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by TPO, DIO1, DIO3, MOCOScytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• (R)-noradrenalineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• a 1-(1-hydroxyalkyl)-sn-glycerolReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by IYD, PAH, AGMO

• (2S)-2-aminobutanoateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by IYD, AADAT, AGXT2

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• glycodeoxycholateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. Glycodeoxycholate amidohydrolase

  Catalysed by IYD, AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by IYD, AADAT, GLYATL2

• N-eicosanoylglycinateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by IYD, AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by IYD, AADAT, BAAT

• N-hexacosanoylglycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by IYD, AADAT, BAAT

• thromboxane B2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLC7A9cytosol, extracellular spaceOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by TPO, SDS, SDSL, SRR and 3 morecytosol, mitochondrial matrix