dodecanoyl-CoA

Two steps

• CHEBI:15727Reach from here →
  1. Lauroyl-CoA hydrolase
  2. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• CHEBI:15746Reach from here →
  1. Lauroyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 2 morecytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by GNPATcytosol

• phosphatidylethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• 11-cis-retinolReach from here →
  1. Lauroyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 5 morecytosol

• phosphatidic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2cytosol

• oxaloacetateReach from here →
  1. Lauroyl-CoA hydrolase
  2. ATP citrate lyase (citrate)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 8-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA hydrolase
  2. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 10-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA hydrolase
  2. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 9-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA hydrolase
  2. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosolOne of 9 routes

• a cholesterol esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by SOAT2, SOAT1cytosol

• anilineReach from here →
  1. Lauroyl-CoA hydrolase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 2 morecytosol

• CHEBI:17312Reach from here →
  1. Lauroyl-CoA hydrolase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• L-cysteineReach from here →
  1. Lauroyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, AWAT2, MOGAT1cytosol

• a triacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 morecytosol

• CHEBI:17927Reach from here →
  1. Lauroyl-CoA hydrolase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrixOne of 4 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 10 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. Lauroyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 6 morecytosolOne of 6 routes

• decanoateReach from here →
  1. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
  2. Decanoyl-CoA hydrolase

  Catalysed by ACADM, ECHS1, ACAA2, HADH and 1 moremitochondrial matrix, cytosolOne of 2 routes

• dodecanalReach from here →
  1. Lauroyl-CoA hydrolase
  2. 2 H+[r] + lauric acid[r] + NADH[r] = H2O[r] + NAD+[r] + dodecanal[r]

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• elaidic acidReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. Lauroyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, peroxisomeOne of 7 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
  2. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by ACADM, ECHS1, ACAA2, HADH and 2 moremitochondrial matrix

• tetradecanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C14:0CoA)
  2. Myristoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• an N-acylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol

• fatty acidReach from here →
  1. Lauroyl-CoA hydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosolOne of 4 routes

• 12-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA hydrolase
  2. alkane 1-monooxygenase (lauric acid)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 2 morecytosolOne of 2 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• a 1,3-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 1 morecytosolOne of 2 routes

• taurineReach from here →
  1. Lauroyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1cytosol

• glycineReach from here →
  1. Lauroyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, mitochondrial matrixOne of 11 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol, lysosomeOne of 2 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C14:0CoA)
  2. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ELOVL6, ELOVL3cytosol

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 2 morecytosol, peroxisomeOne of 2 routes