phosphocholine

Three steps

• itaconyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PHOSPHO1, CHAT, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PHOSPHO1, CHAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by PHOSPHO1, CHATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 5 morecytosolOne of 16 routes

• prostaglandin H2Reach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by PHOSPHO1, CHDH, PTGS1, PTGS2One of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by PHOSPHO1, CHDH, TBXAS1, PTGS2 and 1 more

• guanidinoacetateReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by PHOSPHO1, SLC5A7extracellular space, cytosol

• sphing-4-enineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PHOSPHO1, CHAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PHOSPHO1, CHAT, SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrixOne of 7 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 moreOne of 11 routes

• L-tryptophanReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• beta-alanineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrixOne of 5 routes

• L-asparagineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• L-phenylalanineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• L,L-cystathionineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 30 moreOne of 12 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• an acyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PHOSPHO1, CHAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 4 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by PHOSPHO1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 3 more

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, SLC27A5cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A12extracellular space, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by PHOSPHO1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• a cardiolipinReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 3 moreOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by PHOSPHO1, CHAT, CPT1A, CPT1Bcytosol

• an all-trans-retinyl esterReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• CHEBI:63544Reach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• 1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)

  Catalysed by PCYT1A, PCYT1B, CEPT1, PLA2G10 and 6 moreOne of 4 routes

• hexacosanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by PHOSPHO1, CHDH, ACAD10

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 2 more

• (2E)-octadecenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by PHOSPHO1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 moreOne of 7 routes

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, PLA2G10 and 2 moreOne of 4 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes