N(omega),N('omega)-dimethyl-L-arginine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

536 compounds within 3 steps: 3 in 1, 95 in 2, 438 in 3

Three steps

arsenic triglutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
Catalysed by AGXT2, GSS, AS3MTOne of 3 routes
2-phenylethylamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and phenylalanine (cytosol to extracellular)
3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
Catalysed by AGXT2, SLC7A5, DDCextracellular space, cytosol
CHEBI:18405Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-selenocysteine selenide-lyase (L-alanine-forming)
3. pyridoxine 5'-phosphate:oxygen oxidoreductase
Catalysed by AGXT2, SCLY, PNPOcytosolOne of 3 routes
2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and glutamine (cytosol to extracellular)
3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
Catalysed by AGXT2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol
gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)
Catalysed by AGXT2, GCLC
S-methylmercury-L-cysteineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and methionine (cytosol to extracellular)
3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
Catalysed by AGXT2, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes
D-isoleucineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)
Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membrane
15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione
Catalysed by AGXT2, GSS, MGST3
Xaa-L-Pro dipeptideReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline
Catalysed by AGXT2, SLC1A4, PEPDinner side of the membrane, outer side of the membrane
(6R)-10-formyltetrahydrofolateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate
Catalysed by AGXT2, SHMT1, SHMT2, MTHFD1 and 1 more
(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX1, GPX4
(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX1, GPX4
(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX1, GPX4
(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX1, GPX4
a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX4
glycodeoxycholate 3-sulfateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. Glycodeoxycholate amidohydrolase
3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AGXT2, SULT2A1cytosol
3',5'-diiodo-L-thyronineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
Catalysed by AGXT2, MOCOS, DIO3
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2One of 8 routes
5-(3-methylguanidino)-2-oxopentanoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2One of 4 routes
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
Catalysed by AGXT2, SHMT1cytosolOne of 7 routes
S-disulfanyl-L-cysteineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and cysteine (cytosol to extracellular)
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by AGXT2, SLC7A5, CARS2extracellular space, cytosol
(5Z)-dodecenoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by AGXT2, HADHA, ACAA2, HADHBmitochondrial matrixOne of 2 routes
3-iodothyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO1, DIO3One of 2 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by AGXT2, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
3-iodo-L-thyronineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2
Catalysed by AGXT2, MOCOS, DIO1, DIO3One of 2 routes
(7Z)-tetradecenoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by AGXT2, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes
3'-iodo-L-thyronineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2
Catalysed by AGXT2, MOCOS, DIO1, DIO2One of 2 routes
L-thyronineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
Catalysed by AGXT2, MOCOS, DIO3
thyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO3
3'-iodothyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO1, DIO2One of 2 routes
3,3'-diiodothyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO1, DIO2One of 2 routes
3',5'-diiodothyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO3
3,3',5'-triiodothyronamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by AGXT2, MOCOS, DIO3
(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by AGXT2, HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes
(7Z,10Z)-hexadecadienoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by AGXT2, HADHA, ACADVL, HADHBmitochondrial matrix
(4Z,7Z)-decadienoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by AGXT2, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes
(5Z)-octenoyl-CoAReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by AGXT2, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes
3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal
Catalysed by AGXT2, GSS, GSTP1
glycoursodeoxycholate 3-sulfateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. glycine to glycoursodeoxycholate conversion
3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AGXT2, SULT2A1cytosol
glycochenodeoxycholate 3-sulfateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AGXT2, BAAT, SULT2A1
deoxycholateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. Glycodeoxycholate amidohydrolase
3. Glycodeoxycholate amidohydrolase
Catalysed by AGXT2cytosol
a quinolReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by AGXT2, SLC1A4, PRODH2inner side of the membrane, outer side of the membraneOne of 3 routes
hypochlorous acidReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and chloride (cytosol to extracellular)
3. Peroxidase
Catalysed by AGXT2, SLC6A14, LPOextracellular space, cytosolOne of 4 routes
potassium atomReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and chloride (cytosol to extracellular)
3. transport of chloride (cytosol to extracellular)
Catalysed by AGXT2, SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes
CHEBI:27540Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. medium-chain acyl-CoA ligase (hexanoic acid)
Catalysed by AGXT2, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 6 routes
CHEBI:27760Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-selenocysteine selenide-lyase (L-alanine-forming)
3. Selenocystathionine Lysteine-lyase (deaminating)
Catalysed by AGXT2, SCLY, CTHcytosol
elaidic acidReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. long-chain-fatty-acid-CoA ligase (elaidate)
Catalysed by AGXT2, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
5-hydroxytryptophanReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and tryptophan (cytosol to extracellular)
3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)
Catalysed by AGXT2, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 2 routes
5(S)-HETEReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by AGXT2, GSS, GPX5, GPX1 and 7 morecytosolOne of 2 routes
CHEBI:28701Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Propanoyl-CoA:acetyl-CoA C-acyltransferase
Catalysed by AGXT2, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes