butanoate

Three steps

• prostaglandin F2alphaReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• O-acetyl-(R)-carnitineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 7 moremitochondrial matrix, cytosolOne of 9 routes

• sphing-4-enineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 8 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, mitochondrial matrix

• N-sulfo-D-glucosamineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC22A9, STS, SGSHinner side of the membrane, outer side of the membrane, cytosol

• L-alanineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosol, mitochondrial matrix

• leukotriene C4Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-asparagineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, mitochondrial matrix

• adenosine 5'-phosphosulfateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. ATP:sulfate adenylyltransferase

  Catalysed by SLC22A9, STS, PAPSS1, PAPSS2inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• taurolithocholate 3-sulfateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• an acyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 8 morecytosol, Golgi apparatusOne of 2 routes

• histamineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• kynurenateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 7 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosolOne of 4 routes

• dopamineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosol

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC22A9, STS, SLC4A1inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes

• CHEBI:63544Reach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Utilized Transport

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 moremitochondrial matrix, cytosol, endoplasmic reticulum

• (R)-noradrenalineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 7 routes