butanoate

Three steps

• CHEBI:28701Reach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 7 morecytosol, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC22A9, STS, CYP17A1inner side of the membrane, outer side of the membrane, cytosol, endoplasmic reticulum

• a dicarboxylateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A35, SLC25A34inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• chlorine(.)Reach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Carnitine Transport by Atb0

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• glycocholateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• cholateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• acetateReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. Butyryl-CoA hydrolase
  3. transport of acetate and butyrate (cytosol to extracellular)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC26A2 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• formic acidReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. Butyryl-CoA hydrolase
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. Butyryl-CoA hydrolase
  3. transport of butyrate and propanoate (cytosol to extracellular)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• malonic acidReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLC22A9, STS, SLC25A10inner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Utilized Transport

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• adipic acidReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membrane

• (2R,3R)-tartrateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (S,S)-tartrateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (3R)-citramalateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (3S)-citramalateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Utilized Transport

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Utilized Transport

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• thiosulfateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. Estrone 3-sulfate sulfohydrolase
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• serotoninReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• glycolithocholic acidReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. Butyryl-CoA hydrolase
  3. transport of butyrate and L-lactate (cytosol to extracellular)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 8 morecytosol, extracellular spaceOne of 2 routes

• taurineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 7 morecytosol, mitochondrial matrixOne of 10 routes

• (3S)-3-hydroxybutanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
  3. (S)-3-hydroxybutanoyl-CoA hydro-lyase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 moremitochondrial matrixOne of 2 routes

• (R)-methylmalonyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 6 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 7 routes

• dodecanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Production of Glutaryl Carnitine

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosolOne of 7 routes

• eicosanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 7 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 12 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 5 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. phytanate-CoA ligase

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 4 morecytosolOne of 5 routes

• propanoyl-CoAReach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate

  Catalysed by SLC22A9, ACSM3, ACSS3, ACSS2 and 1 moreinner side of the membrane, outer side of the membrane

• octadecanoyl-CoAReach from here →
  1. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  2. carnitine O-palmitoyltransferase (butyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACSM1, ACSM2A, ACSM3, ACSM2B and 11 morecytosolOne of 15 routes

• prostaglandin E1Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes