CHEBI:17312

Two steps

• 3'-dephospho-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. (2E)-dodecenoyl-CoA formation

  No catalyst recordedcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Production of Glutaryl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. phytanate-CoA ligase

  No catalyst recordedcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 morecytosolOne of 15 routes

• S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
  1. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
  2. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by PAOX, SMOX, SRMcytosol

• propane-1,3-diamineReach from here →
  1. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
  2. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

  Catalysed by PAOX, SMOX, DHPScytosol

• sphing-4-enineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes

• L-methionineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  No catalyst recordedcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by NAGScytosol, mitochondrial matrix

• N(1)-acetylspermineReach from here →
  1. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
  2. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

  Catalysed by PAOX, SMOXcytosolOne of 2 routes

• L,L-cystathionineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• N(1)-acetylspermidineReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2

  Catalysed by PAOXcytosolOne of 3 routes

• an acyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes

• 3-aminopropanalReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. spermidine:oxygen oxidoreductase (spermidine-forming)

  Catalysed by SAT1, SAT2, SMOXcytosol

• N(8)-acetylspermidineReach from here →
  1. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)
  2. N8-acetylspermidine to spermidine conversion

  Catalysed by PAOX, SMOXcytosolOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC27A2, SLC27A5cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes