estrone

Three steps

• glutaryl-CoAReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLC22A24 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• propanoyl-CoAReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLC22A9 and 4 morecytosol, inner side of the membrane, outer side of the membrane

• prostaglandin E1Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• prostaglandin H2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• leukotriene A4Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• N-sulfo-D-glucosamineReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. Estrone 3-sulfate sulfohydrolase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SULT1A3, SULT1E1, SULT1A1, STS and 1 morecytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. Estrone 3-sulfate sulfohydrolase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, STScytosolOne of 11 routes

• leukotriene C4Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. Estrone 3-sulfate sulfohydrolase
  3. ATP:sulfate adenylyltransferase

  Catalysed by SULT1A3, SULT1E1, SULT1A1, STS and 2 morecytosolOne of 4 routes

• taurolithocholate 3-sulfateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• histamineReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• kynurenateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLC22A24 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• dopamineReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. Estrone 3-sulfate sulfohydrolase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SULT1A3, SULT1E1, SULT1A1, STS and 1 morecytosol, extracellular spaceOne of 2 routes

• (R)-noradrenalineReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• ursodeoxycholateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• pentanalReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)
  3. pentanal + NAD(+) + H2O = pentanoate + NADH + 2 H(+)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLC22A9 and 1 morecytosol, inner side of the membrane, outer side of the membrane

• 2-hydroxy-3-methoxy-17beta-estradiolReach from here →
  1. Estradiol-17beta:NADP+ 17-oxidoreductase
  2. unspecific monooxygenase (estradiol-17beta)
  3. 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)

  Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 29 morecytosol

• thromboxane B2Reach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SULT1A3, SULT1E1, SULT1A1, SLCO1B1 and 3 morecytosol, extracellular spaceOne of 2 routes