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Proteins/UNIPROT:Q5TCS8
Broad-specificity nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. For this activity shows the following substrate preference CDP > UDP > ADP > TDP..
Function from UniProtKB (Q5TCS8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
76 statements
76 statements · 6 reference databases · Subject: AK9 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
30 reactions
6 names
Resolves to: AK9
Reaction pageReversibleBalancedEC 2.7.4.3mitochondrial matrix
Human-GEM MAR04004CC BY 4.0Reference data
ADP+CHEBI:16174ATP+MAM01639c
Catalysed by AK2 or AK6 or AK1 or AK7 or AK3 or AK5 or AK9 or AK4 or AK8 or ACAD9
Reaction pageReversibleBalancedEC 2.7.4.11, 2.7.4.3cytosol
Human-GEM MAR04480CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedendoplasmic reticulum, cytosol
Human-GEM MAR04906CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR04907CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04908CC BY 4.0Reference data
Catalysed by NME3 or NME4 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07883CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07886CC BY 4.0Reference data
Catalysed by NME3 or NME4 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07890CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07894CC BY 4.0Reference data
ADP+CHEBI:16039ATP+CHEBI:17808
Catalysed by NME3 or NME4 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07895CC BY 4.0Reference data
Catalysed by AK4 or CMPK1 or CMPK2 or AK9
Reaction pageDirection not assertedBalanced
Rhea RHEA:11600CC BY 4.0Reference data