Proteins/UNIPROT:Q9H4B0

OSGEPL1

ProteinUNIPROT:Q9H4B0tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance..

Function from UniProtKB (Q9H4B0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 4 reference databases · Subject: OSGEPL1 · Sources: Hetionet, Reactome, Rhea, UniProt

Order

OSGEPL1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
OSGEPL1 participates in tRNA modification in the mitochondrionPathwayReactome R-HSA-6787450Inferred only
OSGEPL1 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
BUB1B decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:701-64172Inferred only
CLCN3 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:1182-64172Inferred only
IL20 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:50604-64172Inferred only
NT5C2 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:22978-64172Inferred only
PDCD2 increases the expression of OSGEPL1ProteinHetionet hetionet:regulates:5134-64172Inferred only
PRMT7 increases the expression of OSGEPL1ProteinHetionet hetionet:regulates:54496-64172Inferred only
PSMD1 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:5707-64172Inferred only
RRM1 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:6240-64172Inferred only
SOAT2 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:8435-64172Inferred only

Show the remaining 4

SUZ12 decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:23512-64172Inferred only
VCP decreases the expression of OSGEPL1ProteinHetionet hetionet:regulates:7415-64172Inferred only
OSGEPL1 requires the cofactor divalent metal cationCompoundUniProt Q9H4B0Inferred only
L-threonylcarbamoyladenylate is a substrate of OSGEPL1CompoundRhea RHEA:37059Inferred only

Reactions

1 reaction

L-threonylcarbamoyladenylate+CHEBI:74411CHEBI:74418+AMP+hydron
Catalysed by OSGEPL1 or OSGEP
Reaction pageDirection not assertedBalanced
Rhea RHEA:37059CC BY 4.0Reference data

Other names

7 names

Resolves to: OSGEPL1

Also called: GCP1N6-L-threonylcarbamoyladenine synthaseO-sialoglycoprotein endopeptidase-like protein 1OSGEP-like protein 1t(6)A synthaset(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1

← Every protein Find it in the graph →