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Proteins/UNIPROT:Q15004
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number..
Function from UniProtKB (Q15004), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
827 statements
827 statements · 3 reference databases · Subject: PCLAF · Sources: gene ontology, Hetionet, Reactome · Rows fetched: 300
11 names
Resolves to: PCLAF