Proteins/UNIPROT:P31785

IL2RG

ProteinUNIPROT:P31785

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15..

Function from UniProtKB (P31785), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Omenn syndrome has a germline basis in IL2RGDiseaseGenCC HGNC:6010|MONDO:0011338Inferred only
T-B+ severe combined immunodeficiency due to gamma chain deficiency has a germline basis in IL2RGDiseaseGenCC HGNC:6010|MONDO:0010315Inferred only

Statements

82 statements

82 statements · 4 reference databases · Subject: IL2RG · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

AXL interacts with IL2RGProteinHetionet hetionet:interacts:3561-558Inferred only
CAPNS1 interacts with IL2RGProteinHetionet hetionet:interacts:3561-826Inferred only
GRB2 interacts with IL2RGProteinHetionet hetionet:interacts:2885-3561Inferred only
IL2RG interacts with IL13RA1ProteinHetionet hetionet:interacts:3561-3597Inferred only
IL2RG interacts with IL15ProteinHetionet hetionet:interacts:3561-3600Inferred only
IL2RG interacts with IL15RAProteinHetionet hetionet:interacts:3561-3601Inferred only
IL2 interacts with IL2RGProteinHetionet hetionet:interacts:3558-3561Inferred only
IL2RG interacts with IL21ProteinHetionet hetionet:interacts:3561-59067Inferred only
IL2RB interacts with IL2RGProteinHetionet hetionet:interacts:3560-3561Inferred only
IL2RG interacts with IL4ProteinHetionet hetionet:interacts:3561-3565Inferred only
IL2RG interacts with IL7ProteinHetionet hetionet:interacts:3561-3574Inferred only
IL2RG interacts with IL7RProteinHetionet hetionet:interacts:3561-3575Inferred only

Show the remaining 70

IL2RG interacts with IL9RProteinHetionet hetionet:interacts:3561-3581Inferred only
IL2RG interacts with JAK1ProteinHetionet hetionet:interacts:3561-3716Inferred only
IL2RG interacts with JAK2ProteinHetionet hetionet:interacts:3561-3717Inferred only
IL2RG interacts with JAK3ProteinHetionet hetionet:interacts:3561-3718Inferred only
IL2RG interacts with PTPRJProteinHetionet hetionet:interacts:3561-5795Inferred only
IL2RG interacts with SHBProteinHetionet hetionet:interacts:3561-6461Inferred only
IL2RG interacts with SHC1ProteinHetionet hetionet:interacts:3561-6464Inferred only
IL2RG interacts with STAT1ProteinHetionet hetionet:interacts:3561-6772Inferred only
IL2RG interacts with STAT5AProteinHetionet hetionet:interacts:3561-6776Inferred only
IL2RG interacts with STK4ProteinHetionet hetionet:interacts:3561-6789Inferred only
IL2RG interacts with UBCProteinHetionet hetionet:interacts:3561-7316Inferred only
IL2RG interacts with WWP1ProteinHetionet hetionet:interacts:11059-3561Inferred only
IL2RG interacts with WWP2ProteinHetionet hetionet:interacts:11060-3561Inferred only
IL2RG participates in Atopic dermatitis mechanism and therapiesPathwayWikiPathways WP5538Inferred only
IL2RG participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
IL2RG participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL2RG participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL2RG participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
IL2RG participates in FOXP3 in COVID 19PathwayWikiPathways WP5063Inferred only
IL2RG participates in IL2 signalingPathwayWikiPathways WP49Inferred only
IL2RG participates in IL4 signalingPathwayWikiPathways WP395Inferred only
IL2RG participates in IL7 signalingPathwayWikiPathways WP205Inferred only
IL2RG participates in IL9 signalingPathwayWikiPathways WP22Inferred only
IL2RG participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL2RG participates in Inflammatory bowel disease signalingPathwayWikiPathways WP5198Inferred only
IL2RG participates in Inflammatory response pathwayPathwayWikiPathways WP453Inferred only
IL2RG participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
IL2RG participates in Interactions between immune cells and microRNAs in tumor microenvironmentPathwayWikiPathways WP4559Inferred only
IL2RG participates in Interleukin receptor SHC signalingPathwayReactome R-HSA-912526Inferred only
IL2RG participates in Interleukin-15 signalingPathwayReactome R-HSA-8983432Inferred only
IL2RG participates in Interleukin-2 family signalingPathwayReactome R-HSA-451927Inferred only
IL2RG participates in Interleukin-2 signalingPathwayReactome R-HSA-9020558Inferred only
IL2RG participates in Interleukin-21 signalingPathwayReactome R-HSA-9020958Inferred only
IL2RG participates in Interleukin-3, Interleukin-5 and GM-CSF signalingPathwayReactome R-HSA-512988Inferred only
IL2RG participates in Interleukin-4 and Interleukin-13 signalingPathwayReactome R-HSA-6785807Inferred only
IL2RG participates in Interleukin-7 signalingPathwayReactome R-HSA-1266695Inferred only
IL2RG participates in Interleukin-9 signalingPathwayReactome R-HSA-8985947Inferred only
IL2RG participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
IL2RG participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
IL2RG participates in Measles virus infectionPathwayWikiPathways WP4630Inferred only
IL2RG participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
IL2RG participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
IL2RG participates in Regulatory circuits of STAT3 signalingPathwayWikiPathways WP4538Inferred only
IL2RG participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
IL2RG participates in Signaling by ALKPathwayReactome R-HSA-201556Inferred only
IL2RG participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL2RG participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
IL2RG participates in STAT3 nuclear events downstream of ALK signalingPathwayReactome R-HSA-9701898Inferred only
IL2RG participates in Ulcerative colitis signalingPathwayWikiPathways WP5174Inferred only
IL2RG participates in Uterine natural killer cells and progesterone estrogen and chorionic gonadotropinPathwayWikiPathways WP5569Inferred only
IL2RG regulates negative regulation of apoptotic processBiological processgene ontology P31785|GO:0043066Inferred only
IL2RG regulates negative regulation of Fas signaling pathwayBiological processgene ontology P31785|GO:1902045Inferred only
IL2RG regulates negative regulation of tyrosine phosphorylation of STAT proteinBiological processgene ontology P31785|GO:0042532Inferred only
IL2RG regulates positive regulation of leukocyte differentiationBiological processgene ontology P31785|GO:1902107Inferred only
IL2RG regulates positive regulation of leukocyte proliferationBiological processgene ontology P31785|GO:0070665Inferred only
IL2RG regulates positive regulation of MAPK cascadeBiological processgene ontology P31785|GO:0043410Inferred only
IL2RG regulates positive regulation of phagocytosisBiological processgene ontology P31785|GO:0050766Inferred only
IL2RG regulates positive regulation of T cell differentiationBiological processgene ontology P31785|GO:0045582Inferred only
IL2RG regulates positive regulation of tyrosine phosphorylation of STAT proteinBiological processgene ontology P31785|GO:0042531Inferred only
ATR increases the expression of IL2RGProteinHetionet hetionet:regulates:545-3561Inferred only
C2CD2 increases the expression of IL2RGProteinHetionet hetionet:regulates:25966-3561Inferred only
CCNC increases the expression of IL2RGProteinHetionet hetionet:regulates:892-3561Inferred only
KDM3A increases the expression of IL2RGProteinHetionet hetionet:regulates:55818-3561Inferred only
LIG1 increases the expression of IL2RGProteinHetionet hetionet:regulates:3978-3561Inferred only
MAP4K2 increases the expression of IL2RGProteinHetionet hetionet:regulates:5871-3561Inferred only
MAP4K4 increases the expression of IL2RGProteinHetionet hetionet:regulates:9448-3561Inferred only
PAF1 increases the expression of IL2RGProteinHetionet hetionet:regulates:54623-3561Inferred only
PSMD3 increases the expression of IL2RGProteinHetionet hetionet:regulates:5709-3561Inferred only
RRM1 increases the expression of IL2RGProteinHetionet hetionet:regulates:6240-3561Inferred only
WARS2 increases the expression of IL2RGProteinHetionet hetionet:regulates:10352-3561Inferred only

Other names

7 names

Resolves to: IL2RG

Also called: CD antigen CD132gammaCIL-2 receptor subunit gammaIL-2R subunit gammaIL-2RGInterleukin-2 receptor subunit gammap64

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