Pathway
NOSTRIN mediated eNOS trafficking
eNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellular vesicular structures. NOSTRIN functions as an adaptor protein through homotrimerization and recruitment of eNOS, dynamin-2, and N-WASP to its SH3 domain. Studies indicated that NOSTRIN may facilitate vesicle fission and endocytosis of eNOS by coordinating the function of dynamin and N-WASP, which in turn, recruits the Arp2/3 complex, initiating actin filament polymerization. Overall, this process is thought to occur via caveolar endocytosis.
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: NOSTRIN mediated eNOS trafficking · Sources: Reactome
- CAV1 participates in NOSTRIN mediated eNOS traffickingProteinReactome R-HSA-203641Inferred only
- DNM2 participates in NOSTRIN mediated eNOS traffickingProteinReactome R-HSA-203641Inferred only
- NOS3 participates in NOSTRIN mediated eNOS traffickingProteinReactome R-HSA-203641Inferred only
- NOSTRIN participates in NOSTRIN mediated eNOS traffickingProteinReactome R-HSA-203641Inferred only
- WASL participates in NOSTRIN mediated eNOS traffickingProteinReactome R-HSA-203641Inferred only