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Proteins/UNIPROT:Q02548
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire..
(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity..
Function from UniProtKB (Q02548), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
74 statements
74 statements · 4 reference databases · Subject: PAX5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: PAX5