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Proteins/UNIPROT:P06132
Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I..
Function from UniProtKB (P06132), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
119 statements
119 statements · 3 reference databases · Subject: UROD · Sources: Hetionet, Reactome, WikiPathways
5 reactions
4proton+MAM03127e4carbon dioxide+MAM01605e
Catalysed by UROD
Reaction pageReversibleBalancedEC 4.1.1.37extracellular space
Human-GEM MAR02198CC BY 4.0Reference data
4proton+MAM03128c4carbon dioxide+coproporphyrinogen III
Catalysed by UROD
Reaction pageLeft to rightBalancedEC 4.1.1.37cytosol
2 names
Resolves to: UROD
4proton+MAM03127c4carbon dioxide+MAM01605c
Catalysed by UROD
Reaction pageLeft to rightBalancedEC 4.1.1.37cytosol
Human-GEM MAR04772CC BY 4.0Reference data
CHEBI:57308+4hydroncoproporphyrinogen III+4carbon dioxide
Catalysed by UROD
Reaction pageLeft to rightBalanced
Rhea RHEA:19865CC BY 4.0Reference data
CHEBI:62626+4hydronCHEBI:62631+4carbon dioxide
Catalysed by UROD
Reaction pageLeft to rightBalanced
Rhea RHEA:31239CC BY 4.0Reference data