Proteins/UNIPROT:Q92858

ATOH1

ProteinUNIPROT:Q92858

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)..

Function from UniProtKB (Q92858), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

pontocerebellar hypoplasia has a germline basis in ATOH1DiseaseGenCC HGNC:797|MONDO:0020135Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: ATOH1 · Sources: gene ontology, Hetionet

Order

ATOH1 interacts with HMGB1ProteinHetionet hetionet:interacts:3146-474Inferred only
ATOH1 regulates negative regulation of gliogenesisBiological processgene ontology Q92858|GO:0014014Inferred only
ATOH1 regulates positive regulation of inner ear receptor cell differentiationBiological processgene ontology Q92858|GO:2000982Inferred only
ATOH1 regulates positive regulation of neuron differentiationBiological processgene ontology Q92858|GO:0045666Inferred only
ATOH1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q92858|GO:0045944Inferred only
ATOH1 decreases the expression of DCUN1D4ProteinHetionet hetionet:regulates:474-23142Inferred only
ATOH1 increases the expression of KLHL21ProteinHetionet hetionet:regulates:474-9903Inferred only
ATOH1 increases the expression of NOS3ProteinHetionet hetionet:regulates:474-4846Inferred only
ATOH1 decreases the expression of NOSIPProteinHetionet hetionet:regulates:474-51070Inferred only
ATOH1 increases the expression of SLC35A3ProteinHetionet hetionet:regulates:474-23443Inferred only
ATOH1 decreases the expression of TP53BP2ProteinHetionet hetionet:regulates:474-7159Inferred only
ATOH1 decreases the expression of TRAP1ProteinHetionet hetionet:regulates:474-10131Inferred only

Show the remaining 1

ATOH1 decreases the expression of UFM1ProteinHetionet hetionet:regulates:474-51569Inferred only

Other names

8 names

Resolves to: ATOH1

Also called: ATH1Atonal bHLH transcription factor 1atonal homolog 1BHLHA14Class A basic helix-loop-helix protein 14hATH1Helix-loop-helix protein hATH-1Protein atonal homolog 1

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