Pathway
NOSIP mediated eNOS trafficking
eNOS-interacting protein (NOSIP) is a 34-kDa nucleocytoplasmic shuttling protein that binds to the COOH-terminal region (amino acids 366-486) of the eNOS oxygenase domain. This protein association promotes translocation of eNOS from the plasma membrane caveolae to the cytoskeleton and inhibits eNOS activity. Studies have found that NOSIP accumulates in the cytoplasm specifically during the G2 phase of the cell cycle.
REACT:R-HSA-203754Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: NOSIP mediated eNOS trafficking · Sources: Reactome
- NOS3 participates in NOSIP mediated eNOS traffickingProteinReactome R-HSA-203754Inferred only
- NOSIP participates in NOSIP mediated eNOS traffickingProteinReactome R-HSA-203754Inferred only