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Proteins/UNIPROT:P30556
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C..
(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis..
Function from UniProtKB (P30556), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
90 statements
90 statements · 4 reference databases · Subject: AGTR1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
8 names
Resolves to: AGTR1