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Proteins/UNIPROT:Q9BZQ6
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD. May have alpha 1,2-mannosidase activity (By similarity)..
Function from UniProtKB (Q9BZQ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
19 statements
19 statements · 3 reference databases · Subject: EDEM3 · Sources: Hetionet, Reactome, UniProt
2 reactions
N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)+4waterN(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)+4CHEBI:28563
Catalysed by MAN1A2 or MAN1A1 or EDEM3 or MAN1C1 or MAN1B1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56008CC BY 4.0Reference data
2 names
Resolves to: EDEM3
N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)+3waterN(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)+3CHEBI:28563
Catalysed by MAN1A2 or MAN1A1 or EDEM3 or MAN1C1 or MAN1B1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56028CC BY 4.0Reference data