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Proteins/UNIPROT:Q9UI36
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)..
Function from UniProtKB (Q9UI36), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 2 reference databases · Subject: DACH1 · Sources: gene ontology, Hetionet
2 names
Resolves to: DACH1