Proteins/UNIPROT:P48378

RFX2

ProteinUNIPROT:P48378

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6 (By similarity)..

Function from UniProtKB (P48378), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 4 reference databases · Subject: RFX2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MDFI interacts with RFX2ProteinHetionet hetionet:interacts:4188-5990Inferred only
RFX1 interacts with RFX2ProteinHetionet hetionet:interacts:5989-5990Inferred only
RFX2 interacts with RFX4ProteinHetionet hetionet:interacts:5990-5992Inferred only
RFX2 interacts with RFX6ProteinHetionet hetionet:interacts:222546-5990Inferred only
RFX2 participates in Alstrom syndromePathwayWikiPathways WP5202Inferred only
RFX2 participates in Assembly of the 9+2 motile ciliaPathwayReactome R-HSA-9975924Inferred only
RFX2 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
RFX2 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
RFX2 participates in Transcriptional regulation of multiciliogenesisPathwayReactome R-HSA-9945556Inferred only
RFX2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P48378|GO:0006357Inferred only
RFX2 decreases the expression of ATP6V1DProteinHetionet hetionet:regulates:5990-51382Inferred only
RFX2 decreases the expression of CDC20ProteinHetionet hetionet:regulates:5990-991Inferred only

Show the remaining 5

RFX2 increases the expression of CES1ProteinHetionet hetionet:regulates:5990-1066Inferred only
RFX2 decreases the expression of CNDP2ProteinHetionet hetionet:regulates:5990-55748Inferred only
RFX2 decreases the expression of HIF1AProteinHetionet hetionet:regulates:5990-3091Inferred only
RFX2 decreases the expression of MIFProteinHetionet hetionet:regulates:5990-4282Inferred only
RFX2 decreases the expression of TIMP1ProteinHetionet hetionet:regulates:5990-7076Inferred only

Other names

2 names

Resolves to: RFX2

Also called: DNA-binding protein RFX2Regulatory factor X 2

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