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Proteins/UNIPROT:P05546
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner..
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils..
[Isoform 2]: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro..
Function from UniProtKB (P05546), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
49 statements
49 statements · 3 reference databases · Subject: SERPIND1 · Sources: Hetionet, Reactome, WikiPathways
6 names
Resolves to: SERPIND1