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Proteins/UNIPROT:Q9H479
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines..
Function from UniProtKB (Q9H479), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
13 statements
13 statements · 3 reference databases · Subject: FN3K · Sources: Hetionet, Human-GEM, Reactome
6 reactions
ATP+beta-D-fructoseADP+MAM01844c+proton
Reaction pageLeft to rightBalancedEC 2.7.1.-cytosol
Human-GEM MAR04318CC BY 4.0Reference data
MAM00520c+ATPADP+MAM01848c+proton
Catalysed by FN3K
2 names
Resolves to: FN3K
Human-GEM MAR09466CC BY 4.0Reference data
ADP+MAM01847c+protonATP+MAM01846c
Catalysed by FN3KRP or FN3K or FGGY
Reaction pageReversibleBalancedEC 2.7.1.-cytosol
Human-GEM MAR09467CC BY 4.0Reference data
N(6)-D-ribulosyl-L-lysyl-[protein]+ATP(4-)N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]+ADP(3-)+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48432CC BY 4.0Reference data
N(6)-(D-fructosyl)-L-lysyl-[protein]+ATP(4-)N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]+ADP(3-)+hydron
Catalysed by FN3K
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59832CC BY 4.0Reference data
N(6)-(D-psicosyl)-L-lysyl-[protein]+ATP(4-)N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]+ADP(3-)+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:61392CC BY 4.0Reference data