Pathway
Regulation of gene expression by Hypoxia-inducible Factor
HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 and importin alpha/beta. Once in the nucleus HIF-alpha heterodimerizes with HIF-beta (ARNT) and recruits CBP and p300 to promoters of target genes.
REACT:R-HSA-1234158Reactome
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: Regulation of gene expression by Hypoxia-inducible Factor · Sources: Reactome
- ARNT participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- CA9 participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- CITED2 participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- CREBBP participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- EP300 participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- EPAS1 participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- EPO participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- HIF1A participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- HIGD1A participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only
- VEGFA participates in Regulation of gene expression by Hypoxia-inducible FactorProteinReactome R-HSA-1234158Inferred only