Proteins/UNIPROT:P06731

CEACAM5

ProteinUNIPROT:P06731

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells..

(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer..

Function from UniProtKB (P06731), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 3 reference databases · Subject: CEACAM5 · Sources: gene ontology, Hetionet, Reactome

Order

CEACAM1 interacts with CEACAM5ProteinHetionet hetionet:interacts:1048-634Inferred only
CEACAM5 interacts with CEACAM6ProteinHetionet hetionet:interacts:1048-4680Inferred only
CEACAM5 interacts with DISP3ProteinHetionet hetionet:interacts:1048-57540Inferred only
CEACAM5 interacts with EWSR1ProteinHetionet hetionet:interacts:1048-2130Inferred only
CEACAM5 interacts with HIF1AProteinHetionet hetionet:interacts:1048-3091Inferred only
CEACAM5 interacts with HNRNPMProteinHetionet hetionet:interacts:1048-4670Inferred only
CEACAM5 interacts with SELEProteinHetionet hetionet:interacts:1048-6401Inferred only
CEACAM5 interacts with UQCC2ProteinHetionet hetionet:interacts:1048-84300Inferred only
CEACAM5 participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
CEACAM5 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
CEACAM5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CEACAM5 participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only

Show the remaining 8

CEACAM5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CEACAM5 regulates negative regulation of anoikisBiological processgene ontology P06731|GO:2000811Inferred only
CEACAM5 regulates negative regulation of apoptotic processBiological processgene ontology P06731|GO:0043066Inferred only
CEACAM5 regulates negative regulation of myotube differentiationBiological processgene ontology P06731|GO:0010832Inferred only
CEBPD increases the expression of CEACAM5ProteinHetionet hetionet:regulates:1052-1048Inferred only
CREB1 increases the expression of CEACAM5ProteinHetionet hetionet:regulates:1385-1048Inferred only
GFPT1 decreases the expression of CEACAM5ProteinHetionet hetionet:regulates:2673-1048Inferred only
YKT6 increases the expression of CEACAM5ProteinHetionet hetionet:regulates:10652-1048Inferred only

Other names

6 names

Resolves to: CEACAM5

Also called: Carcinoembryonic antigenCarcinoembryonic antigen-related cell adhesion molecule 5CD antigen CD66eCEACEA cell adhesion molecule 5Meconium antigen 100

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