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Proteins/UNIPROT:O00220
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B..
Function from UniProtKB (O00220), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
75 statements
75 statements · 4 reference databases · Subject: TNFRSF10A · Sources: gene ontology, Hetionet, Reactome, WikiPathways
8 names
Resolves to: TNFRSF10A