Pathway
Co-inhibition by PD-1
Programmed cell death protein 1 (PD-1) is a crucial inhibitory receptor that regulates T cell receptor (TCR) signaling and plays a vital role in maintaining immune homeostasis. PD-1 exerts its suppressive effects both directly, by inhibiting early activation events that are otherwise enhanced by co-stimulatory signals like CD28, and indirectly, by reducing interleukin-2 (IL-2) production, which is essential for T cell proliferation and survival. Upon ligation, PD-1 inhibits the expression of key survival and differentiation factors, such as Bcl-xL, and downregulates transcription factors that are central to effector T cell function, including GATA-3, T-bet, and Eomes. Mechanistically, PD-1 recruits the tyrosine phosphatases SHP-1 and SHP-2 to the immune synapse, leading to the dephosphorylation of critical signaling molecules like the CD3-zeta chain, PI3K, and AKT, thereby attenuating TCR signaling and inhibiting T cell activation and function.
REACT:R-HSA-389948Reactome
What the reference databases state
Statements
180 statements
180 statements · 1 reference database · Subject: Co-inhibition by PD-1 · Sources: Reactome
- ADRM1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- AGO1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- AGO2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- AGO3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- AGO4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- ASH2L participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- ATF3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- B3GNT3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- BRD4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- BTRC participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CCND1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CD274 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
Show the remaining 168
- CD3D participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CD3E participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CD3G participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CD4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CDK4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- COPS5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CREBBP participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CSK participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CSNK2A1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CSNK2A2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CSNK2B participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CTNNB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CUL1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- CUL3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DAD1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DDOST participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DERL1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DERL2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DERL3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- DPY30 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- EED participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- EP300 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- EPAS1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- ERLEC1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- ERLIN1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- ERLIN2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- EZH2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- FOS participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- FOSB participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- GSK3B participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC14 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC18; H2AC19 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC20 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC4; H2AC8 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AC7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AJ participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AX participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2AZ2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC11 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC12 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC13 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC14 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC15 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC17 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC21 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC26 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H2BC9 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H3-3A; H3-3B participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H3C15; H3C14; H3C13 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HIF1A participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DPA1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DPB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DQA1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DQA2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DQB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DQB2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DRA participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DRB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DRB3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DRB4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- HLA-DRB5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- IRF1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- JAK1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- JUN participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- JUND participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- KMT2A participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- KMT2C participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- LCK participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- LEF1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- MAGT1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- MIB2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- MOV10 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- MYC participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- MYCN participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- NEK2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- NFE2L2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- NFKB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- NFKB2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- OS9 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- OST4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- OSTC participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PDCD1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PDCD1LG2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAA1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAA2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAB2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAG1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAG2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PRKAG3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMA7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMB7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMC6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD11 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD12 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD13 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD14 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PSMD8 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PTPN11 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- PTPN6 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RBBP4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RBBP5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RBBP7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RBX1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RELA participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RNF185 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RNF5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RPN1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RPN2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- RPS27A participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- SEL1L participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- SEM1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- SKP1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- SPOP participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- STAT1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- STAT3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- STT3A participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- STT3B participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- SUZ12 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TCF7 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TCF7L1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TCF7L2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TEAD1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TEAD2 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TEAD3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TEAD4 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TMEM258 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TNRC6A participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TNRC6B participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TNRC6C participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- TUSC3 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- UBA52 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- UBB participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- UBC participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- VCP participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- WDR5 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- WWTR1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- YAP1 participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only
- YWHAG participates in Co-inhibition by PD-1ProteinReactome R-HSA-389948Inferred only