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Proteins/UNIPROT:Q8TBB1
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65..
Isoform 2 provides an endocytic scaffold for IGSF5/JAM4..
Function from UniProtKB (Q8TBB1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
144 statements
144 statements · 2 reference databases · Subject: LNX1 · Sources: Hetionet, Reactome
6 names
Resolves to: LNX1