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Proteins/UNIPROT:P84095
Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Acts as an activator of the ELMO-DOCK-Rac pathway. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells..
(Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry..
Function from UniProtKB (P84095), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
78 statements
78 statements · 5 reference databases · Subject: RHOG · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
1 reaction
2 names
Resolves to: RHOG
Rhea RHEA:19669CC BY 4.0Reference data