RECQL

DNA helicase that plays a role in DNA damage repair and genome stability. Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity. Plays a role in restoring regressed replication forks. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions. Does not unwind G-quadruplex DNA. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens..

Function from UniProtKB (P46063), read 2026-09-23. CC BY 4.0.